The Centers for Disease Control and Prevention (CDC) released a report earlier this year on the increase of tick-, flea- and mosquito-borne illnesses in the United States, but don’t panic.
Kurt Vandegrift, assistant research professor of biology at Penn State, works on emerging infectious diseases, and his lab studies ticks. Vandegrift’s lab is part of a National Science Foundation grant studying virus community dynamics. His research group is working to develop solutions that could help stop outbreaks of infectious diseases, like the ones mentioned in the recent CDC report, before they start.
“Mice that live in our houses and garages are reservoirs of some pretty nasty pathogens, like hantavirus,” said Vandegrift. “The only way viruses like these get discovered is if they get into humans and start causing illness.” Read more.
Vaccines are understood to be one of the greatest breakthroughs in modern medicine. Here, Health Europa explores how vaccines have benefitted not only humans but also animals, and limited the transmission of zoonotic diseases.
Treatment using vaccines is understood to be one of the greatest breakthroughs in modern medicine; no single medical intervention method has contributed more to the reduction of fatality and the improvement of quality of life. As a result of vaccinations, smallpox has been eradicated, whilst cases of polio are near eradication. Read more.
Written by Sarah Knapton
Grow-your-own organs could be available for desperately ill patients within five years, after scientists successfully transplanted bioengineered lungs into pigs for the first time.
The team at the University of Texas Medical Branch (UTMB) showed that lab-grown organs were quickly accepted by the animals, and within just two weeks had developed a network of blood vessels. Read more.
Provided by UConn Communications
A team of researchers, including UConn assistant professor of pharmaceutics Raman Bahal, has, for the first time, corrected a genetic mutation in a mammalian fetus using a targeted gene editing technique. The approach offers a potential new pathway for treating inherited genetic disorders during the earliest stages of development.
Every year, an estimated 8 million children are born with severe genetic disorders or birth defects. While genetic conditions can be detected during pregnancy using amniocentesis, there are no treatment options currently to correct the conditions before birth. Read more.
Provided by MgGill University
The immune system can be an important ally in the fight against cancer. A study from McGill scientists published today in Science suggests that the reverse may also be true—that abnormal inflammation triggered by the immune system may underlie the development of stomach tumours in patients with a hereditary cancer syndrome known as Peutz-Jeghers Syndrome (PJS). The findings are likely to prompt a re-thinking of how gastric tumours form in patients with this syndrome and in others with gastrointestinal cancers. They should also open the door to potential new treatments based on targeting inflammation rather than tumour cells. Read more.
Written by Victoria Forster
A new research study has identified a potential new target for therapies that could be used in triple-negative breast cancer, while sparing healthy cells.
The work published in Nature Communications by a U.S.-China team, led by researchers at Scripps Research in California, shows how a protein called Rad52 might be a new therapeutic target in some types of cancer. Rad52 participates in the repair of a certain type of DNA damage called a double-strand-break. Repairing DNA may seem like a good idea and in healthy cells it is, but in cancer cells, it can actually keep them alive in a damaged state and prevent therapies from working properly.
One cancer type that the researchers believe a Rad52-targeting drug might be useful in is that of triple-negative breast cancers, an aggressive form of the disease that affects an estimated 28,000 Americans per year. This type of breast cancer also has a lower survival than many other types, with 77% of women with triple-negative breast cancer surviving for 5 years or more, compared to 93% of women with other types of breast cancer. Read more.
Written by Eric Hamilton
In the treatment of cancer, chemotherapy is a cleaver, not a scalpel. By attacking rapidly dividing cells, chemotherapy effectively fights tumors, but it also ravages healthy cells in the gut, bone marrow, the scalp and other organs, leading to severe side effects. These toxic chemicals save lives, but at a great cost to patient well-being.
In an effort to tip the balance toward the upsides of chemotherapy, Glen Kwon, a professor in the University of Wisconsin–Madison School of Pharmacy, is turning to nanoparticles capable of enhancing these drugs’ therapeutic properties.
In new work recently published in the journal ACS Nano, Kwon’s lab developed a stabilized form of a common chemotherapy agent, gemcitabine, and encased it in nanoparticles capable of slowing down their release. In mouse models of human lung cancer, the improved drug inhibited tumor growth more effectively than standard gemcitabine. Read more.
Scientists have designed a special type of drug that helps the body eat and destroy cancerous cells.
The treatment boosts the action of white blood cells, called macrophages, that the immune system uses to gobble up unwanted invaders. Tests in mice showed the therapy worked for aggressive breast and skin tumours, Nature Biomedical Engineering journal reports.
The US team behind the study hope to begin human trials within a few years. Read more.
Written by Nadia Whitehead,UA College of Medicine
Lifelong cytomegalovirus infection may boost the immune system in old age, when we need it most, according to a study led by University of Arizona researchers.
Our immune system is at its peak when we’re young, but after a certain age, it declines and it becomes more difficult for our bodies to fight off new infections. Read more.
Written by Andy Fell
Rhesus macaque monkeys infected in utero with Zika virus develop similar brain pathology to human infants, according to a report by researchers at the California National Primate Research Center and School of Veterinary Medicine at the University of California, Davis, published June 20 in Nature Communications.
Rhesus macaques may be a suitable model system to study how Zika virus infection during pregnancy affects the fetus and to find ways to prevent, diagnose, mitigate or treat it, said Koen Van Rompay, research virologist at the CNPRC. Read more.