OHSU board votes to negotiate with NIH and possibly transform its primate center into an animal sanctuary
February 9, 2026
Excerpt:
…
Nonetheless, some researchers maintain that newer technologies should be used to complement rather than replace animal models. In their view, animal research remains important for understanding complex biological interactions that are affected by illnesses and diseases and, therefore, is essential for science and drug discovery.
For instance, Americans for Medical Progress, a nonprofit advocacy group that supports the use of animal testing in biomedical research, objected for several reasons, such as what it called a “rapid” 180-day negotiating period and “inconsistency” with the intent of Congress and the NIH. The group cited a 2024 report from the NIH Office of Research Infrastructure Programs projecting increasing demand for nonhuman primates through at least 2028.
“As discussions move forward, it will be essential that the perspectives of the scientific and veterinary communities are included alongside advocacy viewpoints so that decisions reflect both animal welfare realities and the nation’s biomedical research needs,” the group wrote in a statement.
“Modernizing research through non-animal models is important, but changes to nationally supported infrastructure must be grounded in evidence, expertise, and a clear understanding of what alternatives can and cannot currently replace.”
Ed Silverman, STAT
NIH looks to turn primate research center into a sanctuary
February 4, 2026
Excerpt:
The National Institutes of Health wants to transition at least one of seven national primate research centers into an animal sanctuary, aiming to move away from animal testing in favor of alternative methods.
…
But some researchers worry that moving away from animal testing too quickly could mean stalled progress on treatments that could cure disease and save lives.
Naomi Charalambakis, who directs science policy and communications at Americans for Medical Progress, an advocacy group that supports responsible animal testing in biomedical research, cautioned that certain fields of study do not yet have viable alternatives to animal testing.
“What we don’t want to do is prematurely eliminate a model that we really need, and then we run into issues in clinical trials that inevitably hurt patients or delay progress in public health,” Charalambakis said.
Sophie Gardner, Politico
Monkeys to be spared in some US drug trials
December 2, 2025
Excerpt:
The US’s drug regulator said it would stop requiring pharmaceutical companies to use lab monkeys for some safety studies, in a move that will yield substantial savings for the industry.
…
Last month, the UK announced a new strategy for replacing animals in drug testing, pledging £30mn in government funding to promote the use of artificial intelligence and other tools.
Naomi Charalambakis, an official with the non-profit Americans for Medical Progress, said the FDA would probably continue to require animal testing for complicated treatment developments for diseases such as Alzheimer’s and cancer.
“We have to ensure that any new approach that we use maintains or improves the safety and efficacy standards that we are already using rather than simply reducing animal use for the sake of reducing animal use,” Charalambakis said.
Patrick Temple-West, New York, The Financial Times Limited
AMP Publishes Letter to the Editor in STAT
October 27, 2025
In response to an excerpt from the book, “Lab Dog: A Beagle and His Human Investigate the Surprising World of Animal Research,” published in STAT on October 14, AMP emphasizes that specific terminology used in science and research protocols is embedded in a regulatory framework designed to protect animals and ensure consistent care. Read the full response here and below.
Melanie Kaplan’s recent opinion piece, an excerpt from her new book, “Lab Dog: A Beagle
and His Human Investigate the Surprising World of Animal Research,” raises an
important truth: Language shapes how the public understands science. The research
community hasn’t always done enough to explain the words we use or the safeguards
behind them.
However, the excerpt’s claim that this language “hides” reality to be secretive overlooks
important context and may lead readers to misunderstand its true purpose. In animal
research, terminology is not about softening or “soothing” reality; it’s about precision and
accountability. Words like “euthanasia” and “animal model” have specific scientific and
legal meanings that trigger defined welfare standards, training requirements, and
oversight mechanisms. For instance, when a protocol lists “euthanasia,” it activates a chain
of mandated veterinary review, approved methods, and public documentation.
Far from being euphemisms, these are terms embedded in a regulatory framework
designed to protect animals and ensure consistent, humane care. Animal research is
among the most scrutinized areas of science in the U.S. Institutions using regulated
species are inspected by the Department of Agriculture — often unannounced — and those
reports are posted publicly. Federal agencies publish annual counts by species and pain
category, and most major programs also undergo voluntary Association for Assessment
and Accreditation of Laboratory Animal Care accreditation, adding yet another
independent welfare audit beyond what the law requires.
Specialized language isn’t unique to research or animal-related fields. In aviation, for
example, a pilot might use terms like “controlled descent” or “runway incursion” — not to
downplay a problem or avoid plain words like “crash” or “near miss,” but because those
phrases are standardized codes that precisely define the risk and corrective process. They
enable experts, inspectors, and regulators to communicate effectively, allowing every event
to be traced, measured, and corrected under federal oversight, ensuring the issue doesn’t
happen again. Animal research terminology works the same way: it ensures that welfare
and procedural standards are met, not masked.
Nonetheless, the research community can and must do more to communicate
transparently. Scientists, veterinarians, animal care professionals, and compliance experts
share a duty to proactively explain their work and the compassion behind it. Clearer
dialogue that is grounded in facts, not fear, will strengthen public trust and safeguard the
scientific progress that benefits both human and animal health.
— Naomi Charalambakis, Americans for Medical Progress
Published: October 25, 2025
1,200 monkeys held in Maryland for years released from quarantine
Excerpts:
The 7News I-Team has learned 1,296 monkeys, some being held in Frederick, Maryland, are being released to Charles River Labs after more than 2 and a half years in federal custody.
In its second-quarter financial report, Charles River, which purchased the monkeys – valued at $ 27 million – for drug research, states that the Department of the Interior has cleared the way for the monkeys to enter the U.S. legally.
…
Charles River Labs statement:
“Charles River has been caring for the animals since they were imported to the United States.. Over the past several years, the US Department of Justice has been investigating the NHP supply trade. As a result, we have been unable to use certain shipments of NHPs from Cambodia in late 2022 and early 2023 for their intended regulatory-required drug development purposes. In July, the Department of the Interior and the U.S. Fish and Wildlife Service cleared for legal entry into the United States all of the NHP shipments from Cambodia from late 2022 and early 2023 that were under investigation. In addition, we have been informed that the U.S. Department of Justice is no longer conducting investigations into these shipments. These positive developments validate our unwavering commitment to compliance and ethics in all that we do. It also demonstrates our steadfast commitment to animal welfare.”
…
Americans for Medical Progress, an animal research advocacy group, tells 7News:
“The welfare of these animals must remain the top priority. Nonhuman primates are essential to countless areas of lifesaving medical research. We are encouraged by this decision because it helps restore some much-needed stability.”
Published August 29, 2025 By Scott Taylor, ABC 7 News
Facing ‘impossible’ workload, USDA struggles to oversee lab animal welfare
Excerpts:
Employees terrified of being laid off. Shrinking resources combined with unprecedented workloads. The loss of a tool critical to enforcing its mission. Such conditions would strain any organization. But for an already overburdened division of the U.S. Department of Agriculture (USDA) responsible for overseeing the welfare of nearly 800,000 lab animals, they could spell disaster.
…
In the past several years, the Animal and Plant Health Inspection Service (APHIS) has lost more than one-third of its inspectors, witnessed a doubling in the number of entities it has to oversee, and added an entirely new class of animal to its purview. Now, actions by President Donald Trump’s administration threaten to reduce APHIS’s workforce even further, and a recent U.S. Supreme Court case has handicapped the agency’s ability to punish those who violate the federal Animal Welfare Act, which mandates the humane treatment of animals housed in everything from labs to zoos.
“It’s the most challenging time I’ve ever seen for animal care,” says Kevin Shea, a former APHIS administrator who spent more than 4 decades at the agency before retiring in January. If APHIS can’t do its job, he says, “animals will suffer.”
…
In light of these challenges, Kleiman is concerned APHIS will seek to outsource its responsibilities to third-party organizations. A 2021 Science investigation revealed the agency had begun an apparently clandestine policy of conducting more limited inspections of labs accredited by AAALAC International, a private organization of veterinarians and scientists.
…
…Naomi Charalambakis, director of communications and science policy at Americans for Medical Progress, a biomedical research advocacy group, argues that the Rise for Animals analysis exaggerates the appearance of severe infractions at AAALAC-accredited entities by counting less serious violations in the total and by focusing on percentages instead of raw numbers. “Labs also often self-report issues to APHIS that they have already corrected,” she notes, “yet these issues still show up as citations.” Charalambakis acknowledges that AAALAC accreditation is “not a magic guarantee that nothing will ever go wrong,” but she says the analysis “paints a misleading picture of how animal research oversight works in practice.”
Sally Thompson-Iritani, the assistant vice provost responsible for the University of Washington’s animal care program—one of the largest in the United States—says she hasn’t noticed a decrease in the quality of APHIS inspections at her university. “We still get inspected, and they’re still thorough and thoughtful.”
Even if APHIS falters, Thompson-Iritani says universities like hers have long had their own mechanisms to ensure proper animal welfare. Every U.S. institution that receives federal funding for animal research must have an Institutional Animal Care and Use Committee, for example. Still, she says, APHIS provides a valuable service. “I like the idea of holding ourselves accountable and getting outside eyes on things.”
Published August 19, 2025 By David Grimm, Science
OP-ED: Promising technologies are not yet ready to replace animal research
A recent op-ed in The Hill praising the National Institutes of Health’s new initiative to promote human-based technologies as a “major victory for animal ethics in science” oversimplifies a far more complex research landscape. While the piece correctly identifies growing support and development of innovative, non-animal approaches, it is misleading in its framing and overstates what this federal initiative actually signals about the future of animal research.
Animal studies remain essential to both basic and translational science. From mapping brain circuitry to developing life-saving vaccines, the use of animal models has helped scientists uncover core biological mechanisms and test therapies with a degree of whole-organism complexity that no alternative system can yet match. Research involving animals has been directly responsible for major advances in treating cancer, HIV/AIDS, diabetes and countless other diseases.
To suggest that NIH is ready to “leave outdated animal experiments behind” is to paint an unrealistic picture of the current scientific landscape. It implies that non-animal alternatives are fully capable of replacing animal studies across the board. In reality, these technologies — while exciting and valuable — are still evolving and have significant limitations. This kind of oversimplification does a disservice not only to the scientific community but also to public understanding.
Published July 13, 2025 By Alissa Hatfield and Naomi Charalambakis, Opinon Contributors,The Hill
E.P.A. Employees Are Invited to Adopt Soon-to-Be Homeless Lab Rats
Excerpt:
Lab animals are also used to establish lethal doses, a basic measure that determines concentrations at which a toxic chemical is lethal to 50 percent of a test population.
Still, most rats up for adoption at the E.P.A. are sentinel rats, which are used to test for contaminants in the environment. “They just hang out,” said Paula Clifford, executive director of Americans for Medical Progress, a nonprofit that advocates the responsible use of animals in research. “Researchers might check their fecal matter,” she said, or “they might take some blood, and then they test that to see, are there any contaminants in the environment?”
Shutting that research down without developing alternatives could not only risk public health, she said, but could also make E.P.A. scientists more dependent on industry research and less able to verify the safety of chemicals.
Despite E.P.A. staff members’ efforts, some lab animals may not be suitable for adoption. Ones that have been genetically modified or have certain diseases aren’t up for grabs, a person with knowledge of the adoption program said.
Ms. Hirsch, the E.P.A. press secretary, said that animals “ineligible for adoption due to their exposure to harmful pollutants will be given humane end-of-life care.”
As for eligible rats, they make great companions, according to Ms. Clifford, who said she had adopted many former lab residents. “If you can convince people to have rodents in their homes, they’re wonderful pets.”
Published July 3, 2025 By Hiroko Tabuchi, The New York Times
Open Record: Beyond Animals
This podcast episode features a scientist in Wisconsin who explains his work using adult stem cells to create organoids to study the brain and disseases like Alzheimer’s, epilepsy and glioblastoma. AMP’s executive director, Paula Clifford, participated in the episode answering questions about why animal are still needed, how they are cared for and what recent policy announcements mean to the involvement of animals in medical progress.
Published June 26, 2025 by Bryan Polcyn and Jenna Sachs, Open Record – FOX6 Milwaukee
NIH planned to keep testing on beagles through 2026 before halting experiments
After the story aired on WJLA TV, the Americans for Medical Progress reached to 7 News. We provided AMP with some of the same questions we asked other organizations that support animal research. AMP responded with the following answers:
Why did NIH use beagles for experiments? What were they studying?
Beagles, like other animal models, are sometimes used in research because of their size, temperament, and biological similarities to humans. This intramural lab at NIH was studying cardiovascular dysfunction during sepsis—a life-threatening condition that causes ~1.7 million hospitalizations per year. Heart dysfunction in sepsis patients is a very serious complication that increases mortality rates from 20% in those without cardiac dysfunction to 70-90% in those who do have cardiac problems.
Did it ever produce valuable/lifesaving results?
It’s important to remember that basic science research is essential because it uncovers foundational mechanisms of how a disease affects the body or how certain processes work in the body. We need this research to pave the way for clinical breakthroughs, but sometimes this can take many years.
In this case, NIH’s research deepens our understanding of what is going on with a patient’s heart and circulatory system when the body is experience what’s called “septic shock,” something that happens when an infection threatens the entire body and can cause low blood pressure and organs (like the heart) no longer functioning correctly. A lot of times, to help bring levels back to normal, epinephrine is used to help restore blood pressure and improve circulation, especially if their hearts are struggling to get enough blood. But to this day, we still don’t have a good understanding of what the best way to treat someone with these symptoms. Sometimes it’s epinephrine, sometimes it’s norepinephrine, or another type of vasopressor.
So what this study shows is that we need to be careful when using epinephrine in patients with cardiac dysfunction because it can cause harmful, long-lasting stress in other areas of the body, particularly at the tissue level, even after an infusion is given.
Studies like this and retrospective studies in children that were published just a couple of months ago looking at whether epinephrine vs. epinephrine is better for treating pediatric septic shock helps guide clinicians on how to not only potentially save their life but also improve the quality of their life long after discharge, to ensure they don’t have health problems later.
Ending animal experiments now that we can create such sophisticated modeling with AI seems cruel and unnecessary. But is it? Are there still things we need to know for which only living creatures, even cute ones, can effectively provide test results?
Emerging technologies like AI and organ-on-a-chip systems are incredibly exciting, and AMP is a strong advocate for advancing them. But at this stage, they don’t replace the complexity of a whole living organism. For example, the way a drug behaves in the bloodstream, interacts with different organs, or triggers an immune response can’t yet be fully replicated in a dish or on a computer. At least not yet–we still need a full-body system to understand how things are working and make sure these therapies and drugs are safe. It’s not about choosing one model over the other — it’s about using the right tool for the right question. An integrative, complementary approach is how we ensure research is both ethical and effective.
Is AMP a supporter of micro-organ chips as an alternative to animal experiments?
Absolutely. AMP supports innovation across the board — from microphysiological systems to advanced computer modeling — when they help us better understand diseases or predict how a treatment might work. But these models are best used alongside animal studies, not in isolation. Until alternative technologies can consistently answer the full range of biological questions, animal research remains a vital part of scientific progress.
What does AMP think about the recent successful work of citizens, federal lawmakers and organizations that have halted animal research at USDA, NIH and Dept of Veterans Affairs?
Public engagement and accountability are critical in science, and we respect the role of lawmakers and advocates. However, we are concerned that some of these decisions are being made based on optics or pressure campaigns rather than on what’s truly needed to responsibly advance medical knowledge. Scientific progress doesn’t happen in a vacuum. If we prematurely cut off certain types of research without having equally robust alternatives ready, we risk slowing down the development of lifesaving treatments. The goal should be to improve the system — not dismantle it.
Published June 9, 2025 by Scott Taylor, ABC 7 News