Animal Research

Latest Research News

Grow-your-own organs could be here within five years, as scientists prove they work in pigs

Written by Sarah Knapton

Lungs being grown in the lab Photo credit: UTMB

Grow-your-own organs could be available for desperately ill patients within five years, after scientists successfully transplanted bioengineered lungs into pigs for the first time.

The team at the University of Texas Medical Branch (UTMB) showed that lab-grown organs were quickly accepted by the animals, and within just two weeks had developed a network of blood vessels. Read more.

Published Aug 1st, 2018 by The Telegraph

 

Targeted Gene Editing Cures Blood Disorder in Fetal Mice

Provided by UConn Communications

Nanoparticle circulation in an extraembryonic vein (larger vessel) and artery (smaller vessel) three hours after injection. (Gif supplied by Ramon Bahal) Nanoparticle circulation in an extraembryonic vein (larger vessel) and artery (smaller vessel) three hours after injection. Photo credit:(Media/Yale University)

A team of researchers, including UConn assistant professor of pharmaceutics Raman Bahal, has, for the first time, corrected a genetic mutation in a mammalian fetus using a targeted gene editing technique. The approach offers a potential new pathway for treating inherited genetic disorders during the earliest stages of development.

Every year, an estimated 8 million children are born with severe genetic disorders or birth defects. While genetic conditions can be detected during pregnancy using amniocentesis, there are no treatment options currently to correct the conditions before birth. Read more.

Published July 26th, 2018 by UConn Today

Rewriting our understanding of gastric tumors

Provided by MgGill University

Artist rendition of a growing stomach polyp from a Peutz-Jeghers Syndrome patient. The red cells represent pro-inflammatory T cells that promote polyp development. Credit: Ella Maru Studio. Photo credit MedicalXpress

The immune system can be an important ally in the fight against cancer. A study from McGill scientists published today in Science suggests that the reverse may also be true—that abnormal inflammation triggered by the immune system may underlie the development of stomach tumours in patients with a hereditary cancer syndrome known as Peutz-Jeghers Syndrome (PJS). The findings are likely to prompt a re-thinking of how gastric tumours form in patients with this syndrome and in others with gastrointestinal cancers. They should also open the door to potential new treatments based on targeting inflammation rather than tumour cells. Read more.

Published July 26, 2018 by MedicalXpress

New ‘Double Hit’ Strategy May Provide New, Minimally Toxic Therapies For Breast Cancer

Written by Victoria Forster

Photo credit: Forbes/ AP Damian Dovarganes

A new research study has identified a potential new target for therapies that could be used in triple-negative breast cancer, while sparing healthy cells.

The work published in Nature Communications by a U.S.-China team, led by researchers at Scripps Research in California, shows how a protein called Rad52 might be a new therapeutic target in some types of cancer. Rad52 participates in the repair of a certain type of DNA damage called a double-strand-break. Repairing DNA may seem like a good idea and in healthy cells it is, but in cancer cells, it can actually keep them alive in a damaged state and prevent therapies from working properly.

One cancer type that the researchers believe a Rad52-targeting drug might be useful in is that of triple-negative breast cancers, an aggressive form of the disease that affects an estimated 28,000 Americans per year. This type of breast cancer also has a lower survival than many other types, with 77% of women with triple-negative breast cancer surviving for 5 years or more, compared to 93% of women with other types of breast cancer. Read more.

Published July 25, 2918 by Forbes

Nanoparticles improve tumor treatment in mice

Written by Eric Hamilton

Atomic-scale images of gemcitabine-loaded nanoparticles reveal an unusual cylindrical shape. Photo credit; University of Wisconsin- Madison Courtesy of Tony Tam

In the treatment of cancer, chemotherapy is a cleaver, not a scalpel. By attacking rapidly dividing cells, chemotherapy effectively fights tumors, but it also ravages healthy cells in the gut, bone marrow, the scalp and other organs, leading to severe side effects. These toxic chemicals save lives, but at a great cost to patient well-being.

In an effort to tip the balance toward the upsides of chemotherapy, Glen Kwon, a professor in the University of Wisconsin–Madison School of Pharmacy, is turning to nanoparticles capable of enhancing these drugs’ therapeutic properties.

In new work recently published in the journal ACS Nano, Kwon’s lab developed a stabilized form of a common chemotherapy agent, gemcitabine, and encased it in nanoparticles capable of slowing down their release. In mouse models of human lung cancer, the improved drug inhibited tumor growth more effectively than standard gemcitabine. Read more.

Published July 25, 2018 by University of Wisconsin-Madison News

Drug gets body cells to ‘eat and destroy’ cancer

Photo credit BBC News/ Getty Images

Scientists have designed a special type of drug that helps the body eat and destroy cancerous cells.

The treatment boosts the action of white blood cells, called macrophages, that the immune system uses to gobble up unwanted invaders. Tests in mice showed the therapy worked for aggressive breast and skin tumours, Nature Biomedical Engineering journal reports.

The US team behind the study hope to begin human trials within a few years. Read more.

Published by July 3, 2018 by BBC News

Rhesus Macaque Model Offers Route to Study Zika Brain Pathology

Written by Andy Fell

Photo Credit: Kathy West/California Primate Research Center

Rhesus macaque monkeys infected in utero with Zika virus develop similar brain pathology to human infants, according to a report by researchers at the California National Primate Research Center and School of Veterinary Medicine at the University of California, Davis, published June 20 in Nature Communications.

Rhesus macaques may be a suitable model system to study how Zika virus infection during pregnancy affects the fetus and to find ways to prevent, diagnose, mitigate or treat it, said Koen Van Rompay, research virologist at the CNPRC. Read more.

Published June 20, 2018 by UC Davis

The secret to living longer? According to fruit flies, it’s in your gut.

The Secret to Living Longer? It’s in your gut.

New research, published in Scientific Reports, revealed that fruit flies fed a combination of probiotics and an herbal supplement called Triphala led longer, healthier lives.

“The fruit fly is a powerful model system since it retains 70% of the core biochemical pathways in humans; however is simpler allowing researchers to more easily delineate signaling pathways. The same goes with the gut microbiome. In humans, there are thousands of species working together to elicit an effect whereas in flies, there are only 10-20 active species allowing us to study more specifically the impact of a supplemented probiotic on the Drosophila physiology,” Susan Westfall, a former Ph.D. student at McGill University and lead author of the study, explained to ALN. Read more.

Published June 15, 2018 by ALN Magazine

A Shot against Cancer Slated for Testing in Massive Dog Study

Written by Keridwen Cornelius

Dog receiving a vaccination. Photo credit ScientificAmerica/Getty Images

Stephen Johnston dreams of a future in which humans could protect themselves against all types of cancer with a single shot. As the biochemist envisions it, this prophylactic injection would train the immune system to pick off cancerous cells before they could mobilize into malignancies. The catch: many oncology specialists insist this is scientifically impossible.

Critics of the concept say tumor cells are too genetically complex to be consistently thwarted by zeroing in on any one target. Yet Johnston and colleagues at Arizona State University have been working on an experimental inoculation for the past 12 years. They tested blood from hundreds of humans and dogs with cancer to identify potential vaccine targets, then came up with vaccine cocktails and experimentally tested them in hundreds of mice with tumors. The researchers believe they have now identified a recipe that has the right stuff to keep tumors from forming. Johnston says his vaccine cocktail instructions remain unpublished because he made a strategic decision not to release them before securing intellectual property rights. Read more.

Published June 7, 2018 by ScientificAmerica