COVID-19 Resources

COVID-19 Frequently Asked Questions

The following is a list of frequently asked questions about the impacts of the COVID-19 pandemic on research facilities and research animals. AMP will continuously update this document as new data, questions and concerns arise.

Questions About the Role of Animals in the Development of a COVID-19 Vaccine

Question: How are vaccines developed?

Vaccines work by triggering our bodies to develop acquired immunity to specific infectious diseases. Immunity is frequently created by introducing the body to a weakened or dead form of the disease-causing microbe. This essentially teaches the immune system how to fight off infection.

The creation of every vaccine features several important steps. These include cellular work, animal studies and human clinical trials, all of which are necessary in order to develop safe and effective vaccines.

A recent episode of the Lab Rat Chat podcast, a program launched through AMP’s Michael D. Hayre Fellowship in Public Outreach, included discussion about how and why animals are necessary for the development of COVID-19 vaccines. We heard from Dr. Rudolf Bohm, Associate Director and Chief Veterinary Medical Officer at the Tulane National Primate Research Center. The discussion took place in early March, before coronavirus became a serious public health threat in the U.S.

Here’s the excerpt:

The full episode and all other editions of the podcast can be found here.

Additional information: – Vaccine Development, Testing, and Regulation

Question: Why are animals necessary for the development of a COVID-19 vaccine?

Animal studies are required for any and all vaccines to ensure that they are both safe and effective prior to approval for public use. These studies help scientists answer important questions including the following:

      • Is the vaccine effective?
      • Does it provide partial or full protection?
      • How long will protection last? Months? Years?
      • How big of a dose and how many doses are required in order to protect vaccine recipients?
      • Are there side effects? How common are they? How serious are they?

It’s also worth noting that COVID-19 likely began as a bat virus that possibly passed through another animal before infecting humans. Because diseases can be passed from other animals to humans, as they have many times in the past, understanding how diseases and treatments respond in various species is crucial.

Additional information: – Vaccine development

Question: How long have animals been a necessary part of the vaccine development process?

Animal studies have played an essential role in the creation of safe and effective vaccines for several decades: 

      • Research in guinea pigs, goats and horses lead to a diphtheria vaccine. Vaccinations throughout the 1920s and 1930s led to a huge reduction in cases. 
      • A yellow fever vaccine developed in 1937 is still in use today. Monkeys and mice took part in those studies. 
      • In 1955, studies in mice and monkeys lead to the development of the polio vaccine by Dr. Jonas Salk. 
      • The measles vaccine was developed in the 1960s. Monkeys and chickens were involved. 
      • In the 1970s, studies in guinea pigs led to the development of a vaccine to fight chickenpox. 
      • The Ebola vaccine, which was developed in nonhuman primates in 2019, is nearly 100% effective in stopping disease transmission. 

Americans for Medical Progress created a brief video highlighting just a few of these groundbreaking success stories. Feel free to share it with others:

Additional information: Why It Took So Long to Eliminate Measles – HISTORY

The First Measles Vaccine | American Academy of Pediatrics

History of Vaccines – A Vaccine History Project of The College of Physicians of Philadelphia

Question: Because lives are in jeopardy, should animal trials be skipped in this case?

While everyone wants a COVID-19 vaccine to be developed ASAP, there are serious problems and risks that arise if we intend to skip important steps in the development process. This is why even the vaccine candidate currently being tested in humans is also undergoing animal tests.

Over the past few weeks, various experts have highlighted the many serious risks associated with skipping animal tests. For example, one vaccine previously developed to combat another coronavirus that impacted felines actually increased the risk of infection. A separate troubling issue surfaced as researchers worked to create a vaccine following the 2003 outbreak of Severe Acute Respiratory Syndrome (SARS). They found some vaccinated animals developed more severe disease compared with unvaccinated animals when they were exposed to the virus. Yet another risk in the attempt to quickly develop a vaccine is that long-term concerns could be overlooked. In their efforts to create a treatment, scientists need to use all research methods available to determine whether COVID-19 might mutate and cause future infections. Otherwise, any recently introduced vaccine might potentially become obsolete.

Additional information:
Nature – Don’t rush to deploy COVID-19 vaccines and drugs without sufficient safety guarantees

Question: Isn’t a COVID-19 vaccine currently being tested without the use of animals?

No. There are no vaccines that are being tested without animal studies. Those opposed to necessary research in animals have made this claim – but it is untrue. 

A vaccine candidate developed jointly by the National Institutes of Health and a company named Moderna is currently being tested in humans. At the same time, scientists at the NIH are conducting animal studies in parallel. See this story in STAT. In fact, some of the data from those animal studies is already available. As the NIH stated on March 16, the day when the first human study participant received the vaccine: 

“The mRNA-1273 vaccine has shown promise in animal models, and this is the first trial to examine it in humans.”  

The decision to allow both animal and human studies to take place at the same time is not because animal studies are unnecessary. It is because COVID-19 is a highly lethal virus that has rapidly spread around the world causing a global emergency.

The ability to conduct animal and human studies concurrently is also possible because the mRNA vaccination approach has also been analyzed in past studies of related coronaviruses that cause severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS). In addition, several mRNA vaccine studies have taken place in animals in the past. Press releases here, and here from Moderna demonstrate this.

Furthermore, below is a small sampling of past research papers where studies in animals provided important data allowing for the development of mRNA vaccine technology:  

Finally, NIAID Director Dr. Anthony Fauci, M.D., recently spoke about the critical role of animals in developing a safe and effective COVID-19 vaccine. Watch him make these statements here. 

Question: What species of animals are required for the development of a COVID-19 vaccine?

Vaccine development involves a variety of animal species in order to gain critical information about the safety and efficacy of a candidate before it is offered to human volunteers. Mice are playing an important role in current efforts to develop a coronavirus vaccine. According to news reports, it’s also likely that ferrets, hamsters and/or monkeys will also be required. One reason why a variety of species are necessary is because some animals are more susceptible to certain diseases than others. In short, the best animal model is often the one that responds to infection similarly to the way that humans do.

Also, in many cases, researchers might study several different specially bred mouse models of a disease. Together this variation provides important information to assist in developing the safest and most effective treatments possible.

It’s also important to recognize that safety approvals by the FDA regularly require studies in at least two different species in order to reduce risk.

Additional information:
New York Times – These Lab Animals Will Help Fight Coronavirus

Question: How long will it likely take to develop a COVID-19 vaccine?

News reports have claimed the development of a COVID-19 vaccine could take anywhere from several months to several years. The fact is, the answer is unknown simply because it depends on the success of current vaccine development efforts. It’s also important to recognize all the things that will likely need to occur before a vaccine is released to the public. These include:

      • Preclinical testing of vaccine candidates
      • Animal efficacy and safety tests
      • Human clinical trials
      • Federal approvals
      • Creation of a manufacturing pipeline for a vaccine
      • Quality control testing and approvals
      • Vaccine manufacturing
      • Vaccine distribution
      • Vaccine delivery
      • Vaccination timeline needs (if for instance, vaccination requires more than one dose in order to achieve immunity.)

Additional information:
Centers for Disease Control and Prevention – Vaccine Safety
Medical News Today – Coronavirus vaccine: Everything you need to know

Question: What’s the status of the development of a vaccine?

Several vaccine candidates that use a variety of approaches are currently being developed. According to the Regulatory Affairs Professionals Society, more than 30 separate attempts are taking place including two candidates currently being tested in human clinical trials. A list of the various approaches along with the companies and research institutions behind them can be found here.

Despite these aggressive efforts, experts say it’s unlikely a vaccine will be approved for use and available to the public this year. See the information above that explains why this is the case. 

Question: As we wait for a vaccine to be developed, what else is the research community doing to attempt to save lives? 

It’s impossible for the experts to determine how long the pandemic will last. In China, where extensive restrictions were put into place to attempt to contain the disease, recent reports suggest that the situation has improved greatly. However, this is not to say that the outbreak has ended in that country. And predictions about the length of the entire worldwide pandemic have varied from a few months to a year and a half. 

While a vaccine is likely many months off, it is possible that attempts to investigate available drugs and treatments may unearth therapies that could significantly reduce the mortality rate of COVID-19. These kinds of studies are already underway and while there are currently no proven therapies for the disease, it is hoped that one or several can be discovered. Recently, STAT News published a list of experimental drugs to treat COVID-19 and their guesses as to when those might be available or when we may have efficacy data. 

Questions About Many Other Ways Animal Research Will Help End the COVID-19 Pandemic.

Question: In addition to vaccine development, how will animal studies further help us combat COVID-19?

Animal Studies Helped Generate the Existing Drugs Currently Being Tested for Treating Coronavirus  Patients. 

Existing drugs like remdesivir, are being studied to determine whether they can reduce illness and save lives. Prior research, has shown that the drug can prevent MERS coronavirus disease in monkeys. It was also studied in mouse models.. Early results in humans also look hopeful 

New Medications That May Help Patients Fight the Disease Are Being Developed Through Animal Research 

In addition to investigating available drugs, researchers at several universities and biomedical research companies are studying a variety of new treatments to fight COVID-19. One is an oral medication called EIDD-2801, which was designed to interfere with a key mechanism that allows the SARS-CoV-2 virus to reproduce in high numbers. Studies in mice have kept a closely-related coronavirus from reproducing for several days and improved lung function as well.

Pigs Are Helping Us Address the Shortage of Ventilators

We’ve all heard about the shortage of ventilators across the United States and the risks this poses to COVID-19 patients. The lack of these devices has caused several universities and companies to look for ways to rapidly build ventilators with items already on hand. Researchers at the University of Minnesota were able to create a makeshift ventilator made from $150 in parts. We know this solution works thanks in part to a study involving pigs.  

Several Animal Species Are Involved in the Development of Antibody Therapies

One treatment physicians and scientists hope will work is the use of antibodies to combat disease. Specially, engineered mice able to produce antibodies to COVID-19 have been developed by a company that anticipates the therapeutic approach might save lives. Horses are also involved in studies where antibodies might be produced in animals. This same approach was used previously to fight diphtheria. Meanwhile, Belgian scientists say antibodies found in llama blood could help neutralize the coronavirus.

Monkeys Are Answering One of the Most Important Questions About COVID-19 Infections

Of course, antibody therapies only work if antibodies indeed protect people against coronavirus infection. So how do we learn if this is the case? Studies in monkeys provided the first clues back in March. That’s when data was released about research in rhesus macaques. The animals did not develop a coronavirus infection the second time they are exposed to the disease. 

Ferrets May Help Us Battle One of the Deadliest Aspects of COVID-19 Infection

For many patients with serious COVID-19 infections, breathing difficulties, along with the development of pneumonia are some of the most life-threatening aspects of the disease. Recent research has shown ferrets are susceptible to infection. This is good news because the animals have respiratory systems very close to humans, meaning they can aid in studies. Cats can also become infected with SARS-CoV-2. Hamsters may also play an important role in developing treatments. 

Bats Are Helping Us Determine the Origins of COVID-19

Many scientists believe the novel coronavirus initially developed in bats, transitioned through another animal –  perhaps pangolins  – and then began infecting humans. Unsurprisingly,  studies in bats  are helping to determine whether that belief is accurate. A better understanding of how the disease moved into humans will also hopefully help prevent future outbreaks

Animals Are Taking Part in Studies to Determine if Pets Can Pass the Disease to Humans

We have known for several weeks, that dogs and cats can become infected with COVID-19, causing little to no illness in the animals themselves. But does that pose a risk to pet owners? This very important question is being studied and of course, animals are involved in the research. 

And Yes, ALL Coronavirus Vaccines Are Being Developed and Tested in Animals.

Of course, the best way to stop coronavirus is to prevent disease transmission and there is no better way to accomplish this than through vaccination. As NIAID Director Dr. Anthony Fauci recently commented, animal studies will play a critical role in developing a safe and effective COVID-19 vaccine.  

There are of course several efforts currently taking place. One vaccine being developed at the University of Pittsburgh is called PittCoVacc. In rodent studies, the treatment generated “a surge of antibodies” against the new coronavirus within two weeks. 

There is however, some public confusion about one COVID-19 vaccine candidate already being tested in humans. Some news coverage incorrectly suggested that animal studies did not precede human trials of the NIH/Moderna vaccine. However, even the NIAID’s announcement of the clinical trial mentioned the vaccine had “previously shown promise in animal models.” In addition, the very same vaccine approach, which makes use of messenger RNA, has been studied at length, including via several animal studies, to combat SARS and MERS. As the NIAID has explained, this previous work “provided a head start for developing a vaccine candidate to protect against COVID-19 .“ But that’s not all. Animal studies are also taking place at the same time as human trials of the NIH/Moderna vaccine candidate. More information can be found in this news story.  

Several scientists have warned we must be cautious and thoroughly study vaccine candidates in both humans and animals before they are approved for public use. This is because there can be serious health risks associated with vaccines if they are not thoroughly tested. Research must also show they produce long-lasting immunity. A vaccine that quickly loses its effectiveness could allow the disease being targeted to rapidly return. There is also the risk that if they are not developed with the utmost care, vaccines can cause a dangerous phenomenon known as antibody dependent enhancement which leaves the body more vulnerable to severe illness after inoculation.

Questions about animals not involved in COVID-19 research.

Question: What are research organizations doing about the thousands of animals currently not involved in COVID-19 studies

Several health research organizations across the country have publicly disclosed their role in the development of new coronavirus treatments and vaccine candidates. In addition, many have started to communicate about the status of research projects in other areas, including those that involve animals.

At some institutions, leaders have asked research staff to plan for the worst-case scenario where animals might need to be euthanized. Making plans in preparation for a crisis and initiating those plans are two entirely separate things which is why it is important that the public understand the difference between the two.

Question: Why are some institutions talking about euthanizing animals not involved in COVID-19 research?

Many research organizations are requiring employees to work from home unless their job requires them to remain onsite. This is the case because COVID-19 has been shown to be highly contagious and by reducing social interactions we are more likely to reduce transmission from person-to-person. In addition, people can unknowingly become infected several days before symptoms surface, which allows the disease to spread even further. This makes the rapid expansion of cases highly-likely and also a severe risk, one that could push our country’s health delivery capabilities well past their capacity. In addition, responsible research organizations are planning for various scenarios including those where animal care staff might be unable to come to work due to illness.

Because of this, research programs are ensuring that everything is in place to implement disaster plans if needed. Animal care staff are considered essential personnel. They are therefore part of the workforce that continues to go to work each day to ensure the animals in their care have what they need. Leaders at research institutions across the U.S. are planning for various scenarios including those where animal care staff are unable to work due to illness or if resources are not available to provide care for the animals.

Again, planning for the worst-case scenario is not the same as initiating those plans, which is why it is important for the public to understand the difference between the two.

Question: Are animals currently being euthanized?

In response to the previously mentioned concerns about additional disease transmission, many research organizations have made the decision to place non-essential research projects on hold. In several cases this means that projects are being halted and will resume once the outbreak has subsided. In other situations, certain projects cannot easily be placed on hold. In these cases, the involved rodents may need to be humanely euthanized. In situations where this becomes necessary, it is not a step that is being taken lightly.

Question: Some organizations have volunteered to accept research animals from studies that have been halted. Are research institutions transferring their animals to these groups?

There are several reasons why research organizations are unable to transfer animals to groups that have offered to take them. One primary reason is the risk that this would pose to the individuals who receive the animals, likely rodents, as well as the public at large.

Another primary reason this is impossible is the risk it would pose to the animals themselves. Mice and rats involved in research are provided with expert care which includes high quality food and water. They also receive daily health checkups from trained animal care specialists and on-site treatment from veterinarians who are very familiar with rodent health and illness. It would be highly unethical to transfer these animals to individuals who lack the financial resources and expertise required to take care of them. In addition, the vast majority of animal studies in this country take place in rats and mice meaning that a single institution may have tens of thousands of rodents. Even if only a small percentage of these animals were transferred to a private citizen or group, they would not have the space, resources or knowledge required to ensure the safety of these animals, themselves or their neighbors.

Questions about disease transmission risks.

Question: Are pets susceptible to COVID-19 infection and if so, could pet owners be infected by their animals?

According to the Centers for Disease Control and Prevention, there’s currently no evidence that pet animals play a significant role in spreading the virus that causes COVID-19. Therefore, the risk of cats and dogs spreading COVID-19 to people is considered low. However, it’s possible the virus could spread between animals when they interact with one another. As a result, the CDC is advising pet owners to walk their dogs on a leash at least 6 feet away from animals living in other households. Here’s a link to some additional advice from the CDC. At the same time, we know cats, dogs and other species can be infected with SARS-CoV- 2, the virus that causes the novel coronavirus. This is why nonhuman primates, ferrets, cats, hamsters and other animals are being used in studies to better understand the disease and develop new treatments and vaccines.

Question: Which activities are safe and which are more risky during the COVID-19 pandemic?

Several health organizations and experts are providing the public with advice about the likely risks of various common activities including going to the grocery store, eating in restaurants and traveling by airline. The Centers for Disease Control and Prevention has posted information on its website about managing COVID-19 risks while performing daily errands or other actions outside of the house. Here’s a link to that information. The Texas Medical Association has ranked several common activities using a numerical scale with the number “one” signifying low risk activities and “ten” being high risk. That scale can be found at this link.     

Additional resources: 

 NPR: From Camping To Dining Out: Here’s How Experts Rate The Risks Of 14 Summer Activities

New York Times: When 511 Epidemiologists Expect to Fly, Hug and Do 18 Other Everyday Activities Again

Have a question about the impacts of COVID-19 on research organizations and research animals? Email us at