Written by PLOS
New research in mice suggests that chronic infection with intestinal worms indirectly reduces the number of cells in lymph nodes near the skin, inhibiting the immune system’s response to the Bacille Calmette-Guerin (BCG) vaccine for tuberculosis. Xiaogang Feng of Karolinska Institutet in Stockholm, Sweden, and colleagues present these findings in PLOS Pathogens.
Many people worldwide receive the BCG vaccine to boost their immune response to bacteria that cause tuberculosis, lowering risk of the disease. Previous studies have shown that the vaccine, which is injected into the skin, is less effective in people with chronic intestinal worm infections, but the reason for this inhibition was unclear. Read more.
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