New research findings provide insight into the immune system pathways that may be key to developing an effective tuberculosis (TB) vaccine. The study, to be published Thursday in the journal Nature Communications, was supported by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health.
Globally, an estimated 10.4 million new TB cases occurred in 2015, according to the World Health Organization. A TB vaccine called bacille Calmette-Guérin (BCG) is currently used in countries with a high prevalence of TB to prevent severe forms of the disease in children. However, the protection provided against pulmonary TB in adults is very variable, and people vaccinated with BCG are more likely to give false positives on skin tests for TB. Read More.
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