Scientists have found a way to get antibody-based therapies across a key barrier in the brain and deliver a payload of drugs that take aim at an elusive Alzheimer's target.
Thursday, May 26, 2011 - 11:02
After decades of studying the pathological process that wipes out large volumes of memory, scientists at The Feinstein Institute for Medical Research discovered a molecule called c-Abl that has a known role in leukemia also has a hand in Alzheimer’s disease. The finding, reported in the June 14th issue of the Journal of Alzheimer’s Disease, offers a new target for drug development that could stave off the pathological disease process.
Wednesday, May 25, 2011 - 13:12
A cell treatment to prevent new organs being rejected without the need for lifelong courses of immune drugs is showing promise in mice and may one day make human transplants easier, scientists said.
Friday, May 20, 2011 - 13:51
Scientists at Fred Hutchinson Cancer Research Center have found that a protein called alpha-catenin acts as a tumor suppressor and they also have unlocked the mechanism by which this protein controls cell proliferation.
Friday, May 20, 2011 - 12:20
A human drug that both prevents and cures kidney failure in mice sheds light on disabling human mitochondrial disorders, and may represent a potential treatment in people with such illnesses.
Thursday, May 19, 2011 - 11:40
About half of prostate cancers have a genetic anomaly that appears to make tumor cells responsive to a new class of cancer-fighting drugs, a new study from the University of Michigan Comprehensive Cancer Center finds.
Wednesday, May 18, 2011 - 11:11
Researchers studying the life threatening infectious disease sepsis have discovered how the infection can lead to a fatal inflammatory response through blood vessel cells. The research, which is published in EMBO Molecular Medicine, focuses on blocking crucial Matrix Metalloprotease enzymes (MMP) which activate the response.
Wednesday, May 18, 2011 - 09:57
Using a technique that silences genes promoting infection, researchers have developed a novel, topically-applied molecular microbicide capable of preventing HIV transmission. The microbicide is predicted to have long-lasting effects in mice, opening the door to developing an intravaginal microbicide that could protect women against HIV infection potentially for weeks at a time and bolster public health efforts to halt the spread of HIV/AIDS.
Tuesday, May 17, 2011 - 14:49
Scientists have identified a class of naturally occurring bacteria that can strongly inhibit malaria-causing parasites in Anopheles mosquitoes, a finding that could have implications for efforts to control malaria.
Monday, May 16, 2011 - 13:17
A new discovery in mice by researchers at Wake Forest Baptist Medical Center may one day allow doctors to spare some patients with acute myeloid leukemia (AML) from toxic treatments, while also opening the door for new therapeutic research.
Monday, May 16, 2011 - 12:41
In a study published this month, first author Budd A. Tucker said that he and principle investigator Michael J. Young took skin cells from the tails of rats and used chemical processes to turn them into “induced pluripotent stem cells,” then guided them into becoming precursor cells for retinal neurons.
Monday, May 16, 2011 - 11:07
New data offer hints to why Parkinson’s disease so selectively harms brain cells that produce the chemical dopamine, say researchers at Washington University School of Medicine in St. Louis.
Friday, May 13, 2011 - 11:02
For the first time, a vaccine has completely protected monkeys against infection with SIV, a virus related to HIV that infects the animals. Out of 24 immunised rhesus macaques, 12 had long-term protection, with no signs of SIV a year after they were deliberately infected with the virus.
Thursday, May 12, 2011 - 10:04
McGill research team found two distinct disease-causing mutations and saved a baby girl.
Wednesday, May 11, 2011 - 14:20
A common, tiny tropical fish plays a key role in a new model for Cushings disease, giving researchers a powerful tool to conduct extensive searches for effective treatments for this serious hormonal disorder, testing up to 300 drugs weekly.
Tuesday, May 10, 2011 - 10:07
Obesity appears to impair normal muscle function in rats, an observation that could have significant implications for humans, according to Penn State researchers. "Our findings demonstrate that obesity involves more than accumulating excess fat and carrying excess weight," said Rudolf J. Schilder, American Physiological Society postdoctoral fellow in physiological genomics, Penn State College of Medicine. "We show that, during the development of obesity, skeletal muscles fail to adjust their molecular composition appropriately to the increasing body weight. Consequently, the muscles of obese mammals are not properly 'tuned' to the higher body weight they carry."
Tuesday, May 10, 2011 - 09:57
University of Arkansas researchers found a way to use fat development in fruit flies to help understand fat metabolism in other animals, including humans. They have developed a genetic model to study a protein that regulates fat production and storage in fruit flies.
Monday, May 9, 2011 - 13:31
A team from the University of Minnesota Medical School and College of Veterinary Medicine successfully performed heart surgery for tetralogy of Fallot on Duke, a 2-year-old American Staffordshire terrier, at the Veterinary Medical Center on April 11.
Friday, May 6, 2011 - 11:43
Researchers looking for better ways to treat tumours in children say they may have stumbled instead on something even better - a new therapy for lung cancer, Australia's single biggest cancer killer.
Thursday, May 5, 2011 - 23:38
Research shows that the chemotherapy drug taxol (also called paclitaxel) could help improve recovery from spinal cord injuries. Writing in Science,* a team led by Frank Bradke, Ph.D., of the Max Planck Institute of Neurobiology in Martinsried, Germany reports that taxol helps repair spinal connections and improves walking in rats with spinal cord damage.
Thursday, May 5, 2011 - 23:33