A team of researchers led by the Sanger Institute and the University of Cambridge used cutting-edge methods to correct a genetic mutation in stem cells derived from a patient's skin biopsy, and then grew them into fresh liver cells.
Friday, October 14, 2011 - 14:35
Modern medicine’s ability to save lives through organ transplantation has been revolutionized by the development of drugs that prevent the human body from rejecting the transplanted organ. But those antirejection drugs have their own side effects — sometimes serious.
Tuesday, October 11, 2011 - 12:10
Scientists in the US were able to normalise blood sugar levels in diabetic mice by injecting them with a compound, nicotinamide mononucleotide (NMN). At the same time the jabs lowered raised levels of cholesterol and triglyceride blood fats.
Tuesday, October 11, 2011 - 12:01
University of Alabama scientist Harald Sontheimer has become popular with brain cancer patients and their doctors after his ongoing research found that a drug approved to treat Crohn's disease in humans shrinks brain tumors in mice.
Tuesday, October 11, 2011 - 11:48
Over the next five years, National Institutes of Health (NIH)-funded researchers will extensively test and generate data about mice with disrupted genes to gain clues about human diseases. NIH today awarded a set of cooperative agreements totaling more than $110 million to begin the second phase of the Knockout Mouse Project (KOMP).
Thursday, September 29, 2011 - 11:11
Ralph Brinster, a prominent veterinary scientist at the University of Pennsylvania, is to receive the National Medal of Science for his work on transgenic lab animals - research that helped lay the foundation for much of modern biomedicine.
Thursday, September 29, 2011 - 10:52
A protein linked to Alzheimer's disease kills nerve cells that detect odors, according to an animal study in the September 28 issue of The Journal of Neuroscience. The findings shed light on why people with Alzheimer's disease often lose their sense of smell early on in the course of the disease.
Wednesday, September 28, 2011 - 09:58
Our livers can fight back against the immune system — reducing organ rejection but also making us more susceptible to liver disease.
Tuesday, September 20, 2011 - 13:39
Cystic fibrosis (CF), a chronic disease that clogs the lungs and leads to life-threatening lung infections, is caused by a genetic defect in a chloride channel called cystic fibrosis transmembrane conductase regulator (CFTR). Although scientists do not fully understand how or why this defect occurs, a team of researchers at The Hospital for Sick Children (SickKids) in Toronto, Ontario, Canada has found a promising clue: a protein called ubiquitin ligase Nedd4L.
Tuesday, September 20, 2011 - 12:13
Only 40 years ago it was widely believed that if you lived long enough, you would eventually experience serious cognitive decline, particularly with respect to memory. The implication was that achieving an advanced age was effectively equivalent to becoming senile—a word that implies mental defects or illness.
Friday, September 16, 2011 - 13:04
Researchers have shown previously that maternal stress during pregnancy may have negative consequences for the fetus, both in humans and laboratory animals. A new study from the University of Pennsylvania suggests that in mice, such impacts - namely, an increased sensitivity to stress - are passed along even to the fetus' children.
Monday, September 12, 2011 - 14:53
Monday, September 12, 2011 - 14:17
Mayo Clinic researchers have developed a genome-based immunization strategy to fight feline AIDS and illuminate ways to combat human HIV/AIDS and other diseases. The goal is to create cats with intrinsic immunity to the feline AIDS virus. The findings — called fascinating and landmark by one reviewer — appear in the current online issue of Nature Methods.
Monday, September 12, 2011 - 14:10
There’s a new twist on dogs being man’s best friend. Veterinary medicine is providing helpful research for people in surprising ways.
Tuesday, September 6, 2011 - 14:27
Injecting modified bacteria related to those which cause tuberculosis could protect against the lung disease, US scientists say. Experiments on mice showed the injections could completely eliminate tuberculosis bacteria in some cases, Nature Medicine reports.
Tuesday, September 6, 2011 - 14:21
A blood-borne immune factor present in elderly mice contributes to signs of mental decline when injected into young mice, and inhibiting it restores youthfulness in old mice, according to an article published online (August 31) in Nature.
Thursday, September 1, 2011 - 10:36
Researchers funded by the National Institutes of Health have converted stem cells from the human endometrium into insulin-producing cells and transplanted them into mice to control the animals’ diabetes.
Wednesday, August 31, 2011 - 10:13
Reconnecting severed blood vessels is mostly done the same way today — with sutures — as it was 100 years ago, when the French surgeon Alexis Carrel won a Nobel Prize for advancing the technique. Now, a team of researchers at the Stanford University School of Medicine has developed a sutureless method that appears to be a faster, safer and easier alternative.
Tuesday, August 30, 2011 - 12:37
Short-term energy storage in animal cells is usually achieved through the accumulation of glucose, in the form of long and branched chains, known as glycogen. But when this accumulation happens in neurons it is fatal, causing them to degenerate.
Tuesday, August 30, 2011 - 11:23
A new atlas of gene expression in the mouse brain provides insight into how genes work in the outer part of the brain called the cerebral cortex. In humans, the cerebral cortex is the largest part of the brain, and the region responsible for memory, sensory perception and language. Mice and people share 90 percent of their genes so the atlas, which is based on the study of normal mice, lays a foundation for future studies of mouse models for human diseases
Thursday, August 25, 2011 - 13:19