Using animal models, researchers at the University of Cincinnati and Cincinnati Children’s Hospital Medical Center have found a new genetic mutation responsible for deafness and hearing loss associated with Usher syndrome type 1.
Tuesday, October 2, 2012 - 15:29
Animal models contribute significantly to our understanding of molecular mechanisms underlying disease pathologies. However, few models predictably translate preclinical findings into what will happen in humans.
Investigational drugs are able to cure mice from many diseases, but continue to fail in clinical trials. This fact is largely attributed to poor model designs that do not sufficiently reflect the pathophysiology of disease in humans. In addition, tremendous diversity of human genetic background, co-medications, dosing, timing of treatment, and many other factors greatly influence the treatment outcome.
Tuesday, October 2, 2012 - 12:51
An international team of scientists, led from Karolinska Institutet in Sweden, have discovered an entirely new approach to the treatment of type II diabetes. The therapy involves the blockade of signalling by a protein known as VEGF-B and this prevents fat from accumulating in the "wrong" places, such as in muscles and in the heart. As a result the cells within these tissues are once again able to respond to insulin. In experiments on mice and rats, the scientists have managed to both prevent the development of type II diabetes and reverse the progression of established disease.
Monday, October 1, 2012 - 15:34
Studying leukemia in mice, researchers at Washington University School of Medicine in St. Louis have reduced a life-threatening complication of stem cell transplants, the only curative treatment when leukemia returns.
Friday, September 28, 2012 - 11:38
A small African mammal with an unusual ability to regrow damaged tissues could inspire new research in regenerative medicine, a University of Florida study finds.
Thursday, September 27, 2012 - 16:26
In what could be the ultimate in personalized medicine, animals bearing your disease, or part of your anatomy, can serve as your personal guinea pig, so to speak. Some researchers call them avatars, like the virtual characters in movies and online games.
Wednesday, September 26, 2012 - 13:48
A Kansas State University professor's research improving post-surgery pain treatment and osteoarthritis therapy in dogs may help develop better ways to treat humans for various medical conditions.
Wednesday, September 26, 2012 - 10:05
EGFR inhibitors used to fight cancer show surprising efficacy in fly, mouse models of beta amyloid-associated memory loss.
Tuesday, September 25, 2012 - 15:03
Long stretches of DNA once considered inert dark matter appear to be uniquely active in a part of the brain known to control the body’s 24-hour cycle, according to researchers at the National Institutes of Health.
Working with material from rat brains, the researchers found some expanses of DNA contained the information that generate biologically active molecules. The levels of these molecules rose and fell, in synchrony with 24-hour cycles of light and darkness. Activity of some of the molecules peaked at night and diminished during the day, while the remainder peaked during the day and diminished during the night.
Friday, September 21, 2012 - 14:18
By integrating themselves into the germ line of their host, retroviruses change the genetic code of their host. The only known case where this process can be currently observed is in Koalas. As an international team of scientists from Australia, Europe and North America just found out, this process may take longer than expected, with the virus continuing to have a serious pathological impact on the host which may go on for centuries.
Friday, September 21, 2012 - 14:14
Genetically engineered mouse models appear to be the most accurate preclinical predictor of how cancer-fighting drugs are delivered to melanoma patients, a new study has found.
Thursday, September 20, 2012 - 15:14
Venomous reptiles may provide a good source for new drugs for human diseases, researchers in Liverpool say.
Wednesday, September 19, 2012 - 16:01
The absence of a specific type of neuron in the brain can lead to obesity and diabetes in mice report researchers in The EMBO Journal. The outcome, however, depends on the type of diet that the animals are fed.
Wednesday, September 19, 2012 - 15:15
A Univ. of Iowa study suggests there are two root causes of a type of diabetes associated with cystic fibrosis (CF). The findings, made possible using ferrets, which already have sparked a clinical trial, may guide development of new treatments or even help prevent diabetes in patients with CF.
Wednesday, September 19, 2012 - 15:09
In the months after a roadside bomb in Afghanistan blew off part of his left thigh, Sgt. Ron Strang wondered if he would ever be able to walk normally again. But that was two years ago. Now he walks easily, can run on a treadmill and is thinking of a post-military career as a police officer. “If you know me, or know to look for it, you can see a slight limp,” he said. “But everybody else, they go, ‘I would never have guessed.’ ” There is something else they would never have guessed: Sergeant Strang has grown new muscle thanks to a thin sheet of material from a pig.
Tuesday, September 18, 2012 - 13:28
A new wave of experimental vaccines, tested in mice, is the medical community’s latest hope against a powerful staph infection that kills more people in the U.S. than skin cancer and costs as much as $8 billion a year to treat.
Monday, September 17, 2012 - 15:14
Scientists have designed a brain implant that sharpened decision making and restored lost mental capacity in monkeys, providing the first demonstration in primates of the sort of brain prosthesis that could eventually help people with damage from dementia, strokes or other brain injuries.
Friday, September 14, 2012 - 14:29
New research reveals that fruit flies and mammals may share a surprising evolutionary link in how they control body temperature through circadian rhythm, unlocking new ways to study the insects as models of human development and disease.
Friday, September 14, 2012 - 10:26
Researchers have restored the ability to hear in deaf gerbils using implanted human stem cells, achieving what they call a first step in potentially overcoming some causes of hearing loss in people.
Thursday, September 13, 2012 - 11:38
Researchers from Georgetown Lombardi Comprehensive Cancer Center demonstrate, in animals, that maternal exposure to a high-fat diet or excess estrogen during pregnancy can increase breast cancer risk in multiple generations of female offspring — daughters, granddaughters and even great-granddaughters.
Wednesday, September 12, 2012 - 15:34