Short-term energy storage in animal cells is usually achieved through the accumulation of glucose, in the form of long and branched chains, known as glycogen. But when this accumulation happens in neurons it is fatal, causing them to degenerate.
Tuesday, August 30, 2011 - 11:23
A new atlas of gene expression in the mouse brain provides insight into how genes work in the outer part of the brain called the cerebral cortex. In humans, the cerebral cortex is the largest part of the brain, and the region responsible for memory, sensory perception and language. Mice and people share 90 percent of their genes so the atlas, which is based on the study of normal mice, lays a foundation for future studies of mouse models for human diseases
Thursday, August 25, 2011 - 13:19
In a study of the transparent roundworm C. elegans, researchers found that a genetic switch in master neurons inhibits the proper functioning of protective cell stress responses, leading to the accumulation of misfolded and damaged proteins.
Thursday, August 25, 2011 - 12:09
Caffeine guards against certain skin cancers at the molecular level, according to a study appearing online August 15, 2011, in the Proceedings of the National Academy of Sciences (PNAS) that explains how the process likely works.
Thursday, August 18, 2011 - 10:19
Tumors that do not respond to chemotherapy are the target of a cancer therapy that prevents the function of two enzymes in mouse tumor cells, according to Pennsylvania medical researchers.
Tuesday, August 16, 2011 - 10:01
In a recent issue of Cancer Research, Daniel J. Powell, Jr., PhD, a research assistant professor of Pathology and Laboratory Medicine and Obstetrics and Gynecology at the Perelman School of Medicine at the University of Pennsylvania, showed for the first time that engineered human T cells can eradicate deadly human ovarian cancer in immune-deficient mice.
Tuesday, August 9, 2011 - 07:50
In new research that could have implications for improving fertilization in humans and other mammals, life scientists studied interactions between individual sperm and eggs in red abalone, an ocean-dwelling snail, and made precise chemical measurements and physical models of these interactions.
Thursday, August 4, 2011 - 11:56
Researchers at Columbia University Medical Center have discovered the biological mechanism behind age-related loss of muscle strength and identified a drug that may help reverse this process. Their findings were published in the August 2 online edition of Cell Metabolism.
Wednesday, August 3, 2011 - 12:55
Scientists have found a flu "super antibody" called FI6 that can fight all types of influenza A viruses that cause disease in humans and animals and say their discovery may be a turning point in the development of new flu treatments.
Tuesday, August 2, 2011 - 10:24
Every year, millions of people contend with lower back and neck discomfort. With intent to ease their pain, Cornell University engineers in Ithaca and doctors at the Weill Cornell Medical College in New York City have created a biologically based spinal implant that could someday spell relief for these countless sufferers.
Tuesday, August 2, 2011 - 09:39
A drug already approved by the Food and Drug Administration (FDA) to treat high blood pressure may have an equally important effect on brain function, according to new research in monkeys
Friday, July 29, 2011 - 11:31
NIH-funded scientists have developed a strain of mice with a built-in off switch that can selectively shut down the animals' serotonin-producing cells, which make up a brain network controlling breathing, temperature regulation, and mood.
Friday, July 29, 2011 - 09:43
A new University of Minnesota discovery may help bone cancer patients fight their disease more effectively, according to new research published in the September issue of Bone.
Thursday, July 28, 2011 - 13:18
In the July 26 issue of PLoS Biology, Dr. Dongsheng Cai and his research team at Albert Einstein College of Medicine describe a pathway that directs the brain to sense the body's glucose dynamics, and they find that a defect of this glucose sensing process contributes to the development of obesity and related disease.
Wednesday, July 27, 2011 - 10:44
Delicate, threadlike protrusions used by cancer cells when they invade other tissues in the body could also help them escape control mechanisms supposed to eliminate them, a research group led by led by Bradley Davidson in the University of Arizona's department of molecular and cellular biology reports in Nature Cell Biology.
Wednesday, July 27, 2011 - 10:13
Removing a protein from cells located in the brain's reward center blocks the anxiety-reducing and rewarding effects of nicotine, according to a new animal study in the July 27 issue of The Journal of Neuroscience. The findings may help researchers better understand how nicotine affects the brain.
Wednesday, July 27, 2011 - 09:42
Researchers in Ottawa report new hope for the treatment of infants born with serious genetic disorder.
Tuesday, July 26, 2011 - 10:00
A promising gene therapy developed, in part, at Thomas Jefferson University’s Center for Translational Medicine to prevent and reverse congestive heart failure is on the verge of clinical trials, after years of proving itself highly effective in the lab and a large animal study.
Thursday, July 21, 2011 - 13:11
At fertilization, a massive release of the metal zinc appears to set the fertilized egg cell on the path to dividing and growing into an embryo, according to the results of animal studies supported by the National Institutes of Health.
Thursday, July 21, 2011 - 11:50
It has taken nearly a century, but mouse geneticists are finally finishing the work started by Abbie Lathrop. The former schoolteacher from Massachusetts bred many of what became the first laboratory strains of mice in the early 1900s.
Tuesday, July 19, 2011 - 12:59