News Archive

Working with mice, researchers led by Mayumi Ito at New York University have identified a population of stem cells lying beneath the base of the nail that can orchestrate the restoration of a partially amputated digit.

Thursday, June 13, 2013 - 14:04

A team of NIH-supported researchers is the first to show, in mice, an unexpected two-step process that happens during the growth and regeneration of inner ear tip links. Tip links are extracellular tethers that link stereocilia, the tiny sensory projections on inner ear hair cells that convert sound into electrical signals, and play a key role in hearing. The discovery offers a possible mechanism for potential interventions that could preserve hearing in people whose hearing loss is caused by genetic disorders related to tip link dysfunction.

Wednesday, June 12, 2013 - 11:02

The mouse hospital at Beth Israel Deaconess and a few similar ones elsewhere are at the forefront of a new approach to studying human cancers. The mice are given genes that make them develop tumors in the same organs as humans, which means the researchers need scanners to watch the tumors’ growth inside the animals’ bodies. So the mouse hospitals have tiny ultrasound machines, CT and PET scanners, and magnetic resonance imaging machines with little stretchers to slide the mice into the machines. They also have mouse pharmacies to formulate medicines in mouse-size doses and mouse clinical laboratories specially designed to do analyses on minute drops of mouse blood and vanishingly small quantities of mouse urine. That lets them follow cancers’ growth and responses to treatments.

Tuesday, June 11, 2013 - 15:18

Animal studies indicate that delivering chemotherapy through inhalation significantly improves the rate of successfully treating lung tumors.

Monday, June 10, 2013 - 16:03

N.C. State University and Yale University researchers uncovered the developmental pathway to one frog species’ carnivorous diet – helping us to understand our own guts in the process.


Read more here: http://www.newsobserver.com/2013/06/09/2950518/nc-state-research-on-cannibalistic.html#storylink=cpy

Monday, June 10, 2013 - 16:01

The master and his dog are both very nervous. On a Thursday morning in April, Randy Wildebrandt has brought Jazzy, a black, 14-year-old poodle, to the MU veterinary hospital for an examination of a cancerous tumor on her right hind leg. She will be injected with a radioactive liquid for a PET, or positron emission topography scan to determine whether her treatment is shrinking the tumor, then she'll spend a day in isolation while the radiation wears off. Jazzy is one of several dogs receiving experimental treatments through the comparative oncology program at MU. Veterinarians hope they can examine the dogs' responses to the treatments to learn new ways of fighting cancer in humans.

Wednesday, June 5, 2013 - 14:22

If you prod a zebrafish embryo, it will normally twitch its tail and try to escape. By watching embryos that wouldn’t twitch properly, a team of scientists has discovered that a gene called STAC3is the cause of a rare inherited muscle disorder called Native American myopathy (NAM). The team also showed that STAC3 plays an important and previously unrecognized role in muscle contractions.

Tuesday, June 4, 2013 - 15:00

Scientists at the National Institutes of Health, and their colleagues, have discovered that a gene called BACH2 may play a central role in the development of diverse allergic and autoimmune diseases, such as multiple sclerosis, asthma, Crohn's disease, celiac disease, and type-1 diabetes. In autoimmune diseases, the immune system attacks normal cells and tissues in the body that are generally recognized as “self” and do not normally trigger immune responses. Autoimmunity can occur in infectious diseases and cancer.

Monday, June 3, 2013 - 12:32

Researchers at the Perelman School of Medicine, University of Pennsylvania have developed a new gene therapy to thwart a potential influenza pandemic. Specifically, investigators in the Gene Therapy Program, Department of Pathology and Laboratory Medicine, directed by James M. Wilson, MD, PhD, demonstrated that a single dose of an adeno-associated virus (AAV) expressing a broadly neutralizing flu antibody into the nasal passages of mice and ferrets gives them complete protection and substantial reductions in flu replication when exposed to lethal strains of H5N1 and H1N1 flu virus. These strains were isolated from samples associated from historic human pandemics – one from the infamous 1918 flu pandemic and another from 2009.

Thursday, May 30, 2013 - 13:25

Researchers at the Perelman School of Medicine, University of Pennsylvania have developed a new gene therapy to thwart a potential influenza pandemic. Specifically, investigators in the Gene Therapy Program, Department of Pathology and Laboratory Medicine, directed by James M. Wilson, MD, PhD, demonstrated that a single dose of an adeno-associated virus (AAV) expressing a broadly neutralizing flu antibody into the nasal passages of mice and ferrets gives them complete protection and substantial reductions in flu replication when exposed to lethal strains of H5N1 and H1N1 flu virus. These strains were isolated from samples associated from historic human pandemics – one from the infamous 1918 flu pandemic and another from 2009.

Thursday, May 30, 2013 - 13:25

An international team led by researchers at the University of California, San Diego School of Medicine reports that a single injection of human neural stem cells produced neuronal regeneration and improvement of function and mobility in rats impaired by an acute spinal cord injury (SCI).

Tuesday, May 28, 2013 - 14:44

A tiny Australian songbird may hold the answer to discovering the biological source of stuttering, which affects 3 million Americans and is notoriously difficult to treat. A team of Michigan State University scientists will investigate the brain and behavior of the zebra finch in the first in-depth study of whether stuttering stems from a lack of rhythm.

Friday, May 24, 2013 - 14:18

Chris Thomson, a second year veterinary student at University of Minnesota’s College of Veterinary Medicine, has been awarded the 2013 AMP/Michael D. Hayre Fellowship in Public Outreach.  Chris’ program will focus on student-to-student outreach at veterinary schools and conferences across America.

Thursday, May 23, 2013 - 13:07

Two Colorado State University professors have developed a nanostructured surface coating for bone that is expected to help improve the lifetime of bone implants. The research, if proven, could someday help someone replace injured or diseased bone segments without losing the affected limb.

Wednesday, May 22, 2013 - 15:24

Salamanders’ immune systems are key to their remarkable ability to regrow limbs, and could also underpin their ability to regenerate spinal cords, brain tissue and even parts of their hearts, scientists have found.

In research published today in the Proceedings of the National Academy of Sciences researchers from the Australian Regenerative Medicine Institute (ARMI) at Monash University found that when immune cells known as macrophages were systemically removed, salamanders lost their ability to regenerate a limb and instead formed scar tissue.

Tuesday, May 21, 2013 - 14:21

While the effects of acute stroke have been widely studied, brain damage during the subacute phase of stroke has been a neglected area of research. Now, a new study by the University of South Florida reports that within a week of a stroke caused by a blood clot in one side of the brain, the opposite side of the brain shows signs of microvascular injury.

Monday, May 20, 2013 - 14:23

Australian scientists are hoping dogs with dementia will help them devise a treatment for people suffering from the condition.

Thursday, May 16, 2013 - 15:22

When the brain's primary "learning center" is damaged, complex new neural circuits arise to compensate for the lost function, say life scientists from UCLA and Australia who have pinpointed the regions of the brain involved in creating those alternate pathways — often far from the damaged site.

Thursday, May 16, 2013 - 14:50

Scientists at Oregon Health & Science University and the Oregon National Primate Research Center (ONPRC) have successfully reprogrammed human skin cells to become embryonic stem cells capable of transforming into any other cell type in the body. It is believed that stem cell therapies hold the promise of replacing cells damaged through injury or illness. Diseases or conditions that might be treated through stem cell therapy include Parkinson’s disease, multiple sclerosis, cardiac disease and spinal cord injuries.

Wednesday, May 15, 2013 - 12:30

Into brains of newborn mice, researchers implanted human “progenitor cells.” These mature into a type of brain cell called astrocytes. They grew into human astrocytes, crowding out mouse astrocytes. The mouse brains became chimeras of human and mouse, with the workhorse mouse brain cells – neurons – nurtured by billions of human astrocytes. Human astrocytes certainly inspired the mice. Genetically engineered "astrocytes" have improved rodents' memories and learning capabilities.

Friday, May 10, 2013 - 14:07