Laboratory animal research results help explain the mechanisms that underlie the formation of reward-cued spatial memories in both the laboratory model and human dentate gyrus. Understanding this mechanism not only explains the biology of an important form of learning, but may also lead to potential treatments for addiction and obesity.
Tuesday, October 5, 2010 - 10:50
Researchers at the Dana-Farber Cancer Institute in Boston have identified a new type of cell in mice that dampens the immune system and protects the animal's own cells from immune system attack. This "suppressor" cell reduces the production of harmful antibodies that can drive lupus and other autoimmune diseases in which the immune system mistakenly turns on otherwise healthy organs and tissues.
Tuesday, October 5, 2010 - 10:38
The 2010 Lasker~DeBakey Clinical Medical Research Award honors a scientist who discovered Vascular Endothelial Growth Factor (VEGF), a key participant in blood-vessel formation, and exploited this knowledge to devise an effective treatment for wet age-related macular degeneration (AMD). Napoleone Ferrara (Genentech) has provided a therapy that can, for the first time, improve sight for people with this illness, many of whom were previously destined for blindness.
Tuesday, September 21, 2010 - 11:10
The 2010 Albert Lasker Basic Medical Research Award honors two scientists for their discovery of leptin, a hormone that regulates appetite and body weight. Douglas Coleman (Jackson Laboratory) established that an appetite-suppressing substance circulates in the bloodstream and signals a second molecule to curb hunger. Jeffrey M. Friedman (Rockefeller University) isolated the gene that encodes the appetite suppressant and showed that fat cells release it.
Tuesday, September 21, 2010 - 10:34
A team of US researchers has reported that one of the proteins released during rheumatoid arthritis can "completely reverse" cognitive impairment in mice bred with some Alzheimer's symptoms. The GM-CSF protein, released during rheumatoid arthritis, was effective at removing another protein in the Alzheimer's mice, amyloid – a major treatment target for dementia.
Monday, September 20, 2010 - 11:09
As the understanding of the biology of ovarian cancer broadens, there is an increased need to develop treatments that are targeted toward a person's genetic makeup, said a clinician-researcher from Baylor College of Medicine.
Friday, September 17, 2010 - 12:29
Researchers discovered that stress is biologically reprogramming the immune cells that are trying to fight the cancer, transforming them instead from soldiers protecting the body against disease into aiders and abettors. The study found a 30-fold increase in cancer spread throughout the bodies of stressed mice compared to those that were not stressed.
Thursday, September 16, 2010 - 10:55
Scientists at the Southwest Foundation for Biomedical Research (SFBR) in San Antonio have found a gene that causes high levels of bad cholesterol to accumulate in the blood as a result of a high-cholesterol diet.
Wednesday, September 15, 2010 - 13:25
Scientists have found that injecting a particular type of stem cells into infertile female rats can restore the function of their ovaries, and say their findings could pave the way for a similar treatment for humans.
Wednesday, September 15, 2010 - 12:28
The central nervous systems of American cockroaches produce natural antibiotics that can kill off bacteria often deadly to humans, such as methicillin-resistant Staphylococcus aureus (MRSA) and toxic strains of Escherichia coli, scientists said this week.
Wednesday, September 15, 2010 - 09:52
Yale School of Medicine professor Carmen Jane Booth and her team of researchers have developed a new animal model for hemophilia A, a disease that affects the blood’s ability to clot. Their eventual goal is to improve treatment for humans with the disorder, she said. “This is the first and only spontaneous rat model of hemophilia A in the world,” Booth said.
Thursday, September 9, 2010 - 11:20
Researchers have identified a new target for the treatment of lymphoma and are testing a potential new drug in pet dogs afflicted with the disease. At low doses, the compound, called S-PAC-1, arrested the growth of tumors in three of six dogs tested and induced partial remission in a fourth.
Wednesday, September 8, 2010 - 15:03
Using high-resolution microscopy, researchers at the National Institutes of Health have shown how insulin prompts fat cells to take in glucose in a rat model. The findings were reported in the Sept. 8 issue of the journal Cell Metabolism.
Wednesday, September 8, 2010 - 11:44
A chemical that rid mice of malaria-causing parasites after a single oral dose may eventually become a new malaria drug if further tests in animals and people uphold the promise of early findings. The compound, NITD609, was developed by an international team of researchers including Elizabeth A. Winzeler, Ph.D., a grantee of the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health.
Friday, September 3, 2010 - 00:44
Here's good news for anyone trying to lose weight or has osteoporosis: Scientists from Maine are on the trail of a weight loss drug that may revolutionize how we treat these two conditions. In a new research report published in the September 2010 print issue of The FASEB Journal, the researchers describe a newly discovered protein, called "Sprouty," responsible for regulating body fat and bone mass.
Wednesday, September 1, 2010 - 12:46
Scientists from the National Institutes of Health and University of Chicago have found a promising treatment method that in laboratory mice reduces the severity of skin and soft-tissue damage caused by USA300, the leading cause of community-associated Staphylococcus aureus infections in the United States.
Wednesday, September 1, 2010 - 12:29
Current antiepileptic drugs (AEDs) have many side-effects, among others slowing down brain activity, which in turn reduces patients' ability to react. These side-effects could be eliminated if genes that counteract seizures could be introduced into the brain. Professor Merab Kokaia at Lund University in Sweden has obtained promising results in animal experiments.
Monday, August 30, 2010 - 11:14
We don't pay all that much attention to animal tests of experimental treatments. So many approaches that look good early on never make it in the real world. But, let's face it, when it comes to the deadly Ebola and Marburg viruses, you don't want to be testing the effectiveness of treatments in people for viruses that kill them 80 percent or more of the time.
Monday, August 30, 2010 - 10:58
Kissing a frog won't turn it into a prince — except in fairy tales — but frogs may be hopping toward a real-world transformation into princely allies in humanity's battle with antibiotic-resistant infections that threaten millions of people worldwide.
Friday, August 27, 2010 - 12:25
An international study led by biologists and neuroscientists from the University of Pennsylvania has identified a new genetic risk factor for amyotrophic lateral sclerosis, commonly known as ALS or Lou Gehrig’s disease.
Friday, August 27, 2010 - 12:13