Finding a drug that can cross the blood-brain barrier is the bane of drug development for Alzheimer's disease and other neurological disorders of the brain. A new Penn study, published this week in the Journal of Neuroscience, has found and tested in an animal model of Alzheimer's disease a class of drug that is able to enter the brain, where it stabilizes degenerating neurons and improves memory and learning.
Tuesday, October 19, 2010 - 11:21
Deaf people with enhanced vision can thank otherwise idle brain cells for their heightened sense, a new study in cats suggests. That's because the brain recruits cells normally devoted to hearing to help them see better, the research revealed.
Monday, October 18, 2010 - 11:52
Very little is known about the causes of pancreatic cancer. However, the discovery of a protein that produces cancerous cells has led University of Minnesota researchers Ashok Saluja, Gunda Georg, and Selwyn Vickers to the drug Minnelide.
Monday, October 18, 2010 - 10:59
Most human cells have 23 pairs of chromosomes, the large bundles of DNA that store all of a cell’s genetic information. However, scientists realized more than 100 years ago that tumor cells usually have extra copies of some chromosomes. This trait, known as aneuploidy, appears to give tumor cells a survival edge.
Thursday, October 7, 2010 - 14:52
Wednesday, October 6, 2010 - 10:57
Thanks to a discovery by a Saint Louis University researcher, scientists have identified an important microRNA that may allow us to better control cholesterol levels in blood.
Tuesday, October 5, 2010 - 15:33
Laboratory animal research results help explain the mechanisms that underlie the formation of reward-cued spatial memories in both the laboratory model and human dentate gyrus. Understanding this mechanism not only explains the biology of an important form of learning, but may also lead to potential treatments for addiction and obesity.
Tuesday, October 5, 2010 - 10:50
Researchers at the Dana-Farber Cancer Institute in Boston have identified a new type of cell in mice that dampens the immune system and protects the animal's own cells from immune system attack. This "suppressor" cell reduces the production of harmful antibodies that can drive lupus and other autoimmune diseases in which the immune system mistakenly turns on otherwise healthy organs and tissues.
Tuesday, October 5, 2010 - 10:38
The 2010 Lasker~DeBakey Clinical Medical Research Award honors a scientist who discovered Vascular Endothelial Growth Factor (VEGF), a key participant in blood-vessel formation, and exploited this knowledge to devise an effective treatment for wet age-related macular degeneration (AMD). Napoleone Ferrara (Genentech) has provided a therapy that can, for the first time, improve sight for people with this illness, many of whom were previously destined for blindness.
Tuesday, September 21, 2010 - 11:10
The 2010 Albert Lasker Basic Medical Research Award honors two scientists for their discovery of leptin, a hormone that regulates appetite and body weight. Douglas Coleman (Jackson Laboratory) established that an appetite-suppressing substance circulates in the bloodstream and signals a second molecule to curb hunger. Jeffrey M. Friedman (Rockefeller University) isolated the gene that encodes the appetite suppressant and showed that fat cells release it.
Tuesday, September 21, 2010 - 10:34
A team of US researchers has reported that one of the proteins released during rheumatoid arthritis can "completely reverse" cognitive impairment in mice bred with some Alzheimer's symptoms. The GM-CSF protein, released during rheumatoid arthritis, was effective at removing another protein in the Alzheimer's mice, amyloid – a major treatment target for dementia.
Monday, September 20, 2010 - 11:09
As the understanding of the biology of ovarian cancer broadens, there is an increased need to develop treatments that are targeted toward a person's genetic makeup, said a clinician-researcher from Baylor College of Medicine.
Friday, September 17, 2010 - 12:29
Researchers discovered that stress is biologically reprogramming the immune cells that are trying to fight the cancer, transforming them instead from soldiers protecting the body against disease into aiders and abettors. The study found a 30-fold increase in cancer spread throughout the bodies of stressed mice compared to those that were not stressed.
Thursday, September 16, 2010 - 10:55
Scientists at the Southwest Foundation for Biomedical Research (SFBR) in San Antonio have found a gene that causes high levels of bad cholesterol to accumulate in the blood as a result of a high-cholesterol diet.
Wednesday, September 15, 2010 - 13:25
Scientists have found that injecting a particular type of stem cells into infertile female rats can restore the function of their ovaries, and say their findings could pave the way for a similar treatment for humans.
Wednesday, September 15, 2010 - 12:28
The central nervous systems of American cockroaches produce natural antibiotics that can kill off bacteria often deadly to humans, such as methicillin-resistant Staphylococcus aureus (MRSA) and toxic strains of Escherichia coli, scientists said this week.
Wednesday, September 15, 2010 - 09:52
Yale School of Medicine professor Carmen Jane Booth and her team of researchers have developed a new animal model for hemophilia A, a disease that affects the blood’s ability to clot. Their eventual goal is to improve treatment for humans with the disorder, she said. “This is the first and only spontaneous rat model of hemophilia A in the world,” Booth said.
Thursday, September 9, 2010 - 11:20
Researchers have identified a new target for the treatment of lymphoma and are testing a potential new drug in pet dogs afflicted with the disease. At low doses, the compound, called S-PAC-1, arrested the growth of tumors in three of six dogs tested and induced partial remission in a fourth.
Wednesday, September 8, 2010 - 15:03
Using high-resolution microscopy, researchers at the National Institutes of Health have shown how insulin prompts fat cells to take in glucose in a rat model. The findings were reported in the Sept. 8 issue of the journal Cell Metabolism.
Wednesday, September 8, 2010 - 11:44
A chemical that rid mice of malaria-causing parasites after a single oral dose may eventually become a new malaria drug if further tests in animals and people uphold the promise of early findings. The compound, NITD609, was developed by an international team of researchers including Elizabeth A. Winzeler, Ph.D., a grantee of the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health.
Friday, September 3, 2010 - 00:44